Department of Applied Chemistry and Bio Engineering

As of March 2018

Inorganic Materials Laboratory

(URL:http://achem.okayama-u.ac.jp/iml/)

Tatsuo FUJII, Professor

Jun KANO, Associate Professor

Makoto NAKANISHI, Assistant Professor

Research Themes:

  • Characterization of Functional Ceramic Thin Films and Nano-particles
  • Developments of Advanced Magnetic Oxides by Soft Chemical Methods
  • Biogenous Iron Oxides for Novel Nanometric Materials
  • Design of New Catalysts Assisted by Ferroelectricity
  • Electronic Structure of Ferroelectrics

Representative Publication :

  • T. Fujii, T. Numata, H. Nakahata, M. Nakanishi, J. Kano, N. Ikeda, Growth and charge ordering of epitaxial YbFe2O4 films on sapphire using Fe3O4 buffer layer, Jpn. J. Appl. Phys. vol. 57, 010305 (3p), 2018
  • N. Oshime, J. Kano, N. Ikeda, T. Teranishi, T. Fujii, T. Ueda, T. Ohkubo, Quantitative study of band structure in BaTiO3 particles with vacant ionic sites, J. Appl. Phys. vol. 120, 154101 (6p), 2016

Inorganic Solid State Chemistry Laboratory

(URL: )

Akira KISHIMOTO, Professor

Hidetaka HAYASHI, Associate Professor

Takashi TERANISHI, Assistant Professor

Research Themes:

  • High Performance Refractory Ceramics Utilizing Superplasticity
  • Enhanced Ion Transport under Millimeter-wave Irradiation
  • Composite Coating from Non-cloudy Electroplating Bath
  • Analysis of Broadband Frequency Response in Oxide Materials
  • Development of Battery with Ultrahigh Rate Capability Utilizing Dielectric Polarization

Representative Publication :

  • Salmie S. C. Abdullah, T. Teranishi, H. Hayashi and A. Kishimoto,"Millimeter-wave irradiation heating for operation of doped CeO2 electrolyte-supported single solid oxide fuel cell", J. Power Sources, Vol.374, pp.92-96 , January 2018

Polymeric Materials Laboratory

(URL:http://achem.okayama-u.ac.jp/polymer/index.html)

Tetsuya UCHIDA, Associate Professor

Takumi OKIHARA, Senior Assistant Professor

Research Themes:

  • Nanomaterials of High-Performance Polymers
    - Creation of Super Materials by Novel Methodology for Morphology Control -
  • Development of a Retinal Prosthesis by Using Photoelectric Dye-Coupled Polyethylene Films (Okayama University-Type Retinal Prosthesis)
  • Functionalized Polysaccharide Material
  • Microwave Assisted Polymeric Material Processing
  • Biodegradable Polymeric Composite Material

Representative Publication :

  • Tomohiro Takahata, Takumi Okihara, Yasuhiro Yohida, Kumiko Yoshihara, Yasuyuki Shiozaki, Aki Yoshida, Kentaro Yamane, Noriyuki Watanabe, Masahide Yoshimura, Mariko Nakamura, Masao Irie, Bart Van Meerbeek, Masato Tanaka, Toshifumi Ozaki and Akihiro Matsukawa, “Bone Engineering by Phosphorylated-Pullulan and β-TCP Composite”, Biomedical Materials, Vol. 10, No. 6, pp. 065009, November 2015.
  • Tetsuya Uchida, Fumiaki Iwaguro, Risa Yanai and Haruka Dodo “Preparation of cellulose nanofibers coated with poly(vinyl alcohol) crystals and their application in composite films” RSC Advances, Vol.7, 19828-19832 (2017)

Fluid & Particle Process Engineering Laboratory

(URL:http://achem.okayama-u.ac.jp/chemeng/index.html)

Kuniaki GOTOH, Professor

Koichi NAKASO, Associate Professor

Yasushi MINO, Assistant Professor

Research Themes:

  • Particle and Powder Characterization (Adhesion, Dustiness and Flowability)
  • Development and Improvement of Powder Unit Operations (Classification, Dispersion, Removal and Uniaxial Compression)
  • Heat and Mass Transfer in Powder Process
  • Effective Utilization of Energy (Chemical Thermal Energy Storage, Heat Transfer Enhancement)
  • Numerical simulations of colloid and powder dynamics (lattice Boltzmann method, discrete element method)

Representative Publication :

  • Kuniaki Gotoh, Kenta Mizutani, Yoshiaki Tsubota, Jun Oshitani, Mikio Yoshida and Ken Inenaga, “Enhancement of Particle Removal Performance of High-speed Air Jet by Setting Obstacle in Jet Flow,” Particulate Science and Technology, 33, pp. 567-571, 2015.
  • Koichi Nakaso, Yuuki Tanaka, Shotaro Eshima, Shunsuke Kobayashi, Jun Fukai,,“Performance of a Novel Steam Generation System Using a Water-zeolite Pair for Effective Use of Waste Heat From the Iron and Steel Making Process,” ISIJ International, 55(2), pp.448-456, 2015.
  • Yasushi Mino, Shohei Sakai, Hiroyuki Shinto and Hideto Matsuyama, “Effect of internal mass in the lattice Boltzmann simulation of moving solid bodies by the smoothed-profile method,” Physical Review E, 95, 043309, 2017.

Interface Process Engineering Laboratory

(URL:http://achem.okayama-u.ac.jp/interface/en-home/)

Tsutomu ONO, Professor

Takaichi WATANABE, Assistant Professor

Research Themes:

  • Nanofiber Wet-Spinning
  • Polymeric Ionic Liquid and Ionic Liquid Interface
  • Microfluidics for Chemical Process
  • Polymer Particles and Capsules
  • Material Design for Drug Delivery

Representative Publication :

  • Takaichi Watanabe, Tsutomu Ono and Yukitaka Kimura, “Continuous Fabrication of Monodisperse Polylactide Microspheres by Droplet- to-Particle Technology Using Microfluidic Emulsification and Emulsion-Solvent Diffusion,” Soft Matter, 7, pp. 9894-9897, August 2011.
  • Takaichi Watanabe, Yui Sakamoto, Tetsuya Inooka, Yukitaka Kimura, Tsutomu Ono “Indocyanine green-laden poly(ethylene glycol)-block-polylactide (PEG-b-PLA) nanocapsules incorporating reverse micelles: Effects of PEG-b-PLA composition on the nanocapsule diameter and encapsulation efficiency” Colloids Surf., A: Physicochem. Eng. Asp., 520, pp. 764-770, May 2017.

Synthetic Process Chemistry Laboratory

(URL:http://achem.okayama-u.ac.jp/reacteng/)

Seiji SUGA, Professor

Koichi MITSUDO, Associate Professor

Hiroki MANDAI, Assistant Professor

Research Themes:

  • Integrated Organic Synthesis
  • Organic Transformations Based on the Electron-Transfer Reaction
  • Synthetic Methods for Heteroacenes
  • Organocatalysts in Asymmetric Synthesis
  • Organic Synthesis Using Microreactor Technology

Representative Publication :

  • Hiroki Mandai, Kazuki Fujii, Hiroshi Yasuhara, Kenko Abe, Koichi Mitsudo, Toshinobu Korenaga and Seiji Suga, "Enantioselective Acyl Transfer Catalysis by a Combination of Common Catalytic Motifs and Electrostatic Interactions," Nature Communications, Vol.7, pp. 11297, April 2016.

Synthetic Organic Chemistry Laboratory

(URL: )

Tadashi EMA, Professor

Kazuto TAKAISHI, Senior Assistant Professor

Chihiro MAEDA, Assistant Professor

Research Themes:

  • Synthesis of Functional Molecules Driven by Intermolecular Forces
  • Development of Catalysts Inspired by Catalytic Principles of Enzymes
  • Synthesis and Application of Functional Dyes Based on Porphyrins and Oligonaphthalenes
  • Chemical Fixation of CO2

Representative Publication :

  • Tadashi Ema, Yuki Miyazaki, Junta Shimonishi, Chihiro Maeda and Jun-ya Hasegawa, “Bifunctional Porphyrin Catalysts for the Synthesis of Cyclic Carbonates from Epoxides and CO2: Structural Optimization and Mechanistic Study,” Journal of the American Chemical Society, Vol. 136, No. 43, pp. 15270-15279, September 2014.
  • Chihiro Maeda, Tomoya Taniguchi, Kanae Ogawa and Tadashi Ema, “Bifunctional Catalysts Based on m-Phenylene-Bridged Porphyrin Dimer and Trimer Platforms: Synthesis of Cyclic Carbonates from Carbon Dioxide and Epoxides,” Angewandte Chemie International Edition, Vol. 54, No. 1, pp. 134-138, January 2015.
  • Kazuto Takaishi, Takahiro Yamamoto, Sakiko Hinoide and Tadashi Ema, “Helical Oligonaphthodioxepins Showing Intense CPL in Solution and in the Solid State.” Chemistry -An European Journal, Vol. 23, No. 39, 9249-9252, June 2017.

Organometallic Chemistry Laboratory

(URL:http://achem.okayama-u.ac.jp/omc/)

Kazuhiko TAKAI, Professor

Masahito MURAI, Assistant Professor

Sobi ASAKO, Assistant Professor

Research Themes:

  • Development of Novel Catalytic Processes for Green-Sustainable Chemistry
  • Invention of Highly Selective Synthetic Reactions with Novel Organometallic Species
  • Activation of Metals and Control of Electron Transfer Process from Low-Valent Metals to Organic Compounds
  • Creation of Novel Organometallic Reactive Species and Their Structure Determination

Representative Publication :

  • Masahito Murai, Ryuji Taniguchi, Naoki Hosokawa, Yuusuke Nishida, Hiroko Mimachi, Tosiyuki Oshiki, and Kazuhiko Takai, “Structural Characterization and Unique Catalytic Performance of Silyl Group-Substituted Geminal Dichromiomethane Complexes Stabilized with a Diamine Ligand,” J. Am. Chem. Soc. Vol. 139, No. 37, pp. 13184-13192, August 2017.
  • Masahito Murai, Erika Uemura, Shunsuke Hori, and Kazuhiko Takai, “ Rhenium-Catalyzed Construction of Polycyclic Hydrocarbon Frameworks by a Unique Cyclization of 1,n-Diynes Initiated by 1,1-Difunctionalization with Carbon Nucleophiles,” Angew. Chem. Int. Ed., Vol. 56, No. 21, pp. 5862-5866, April 2017.
  • Sobi Asako, Takahisa Sakae, Masahito Murai, and Kazuhiko Takai, “Molybdenum-Catalyzed Stereospecific Deoxygenation of Epoxides to Alkenes,” Adv. Synth. Catal. Vol. 358, No. 24, pp. 3966-3970, November 2016.

Heteroatom Chemistry Laboratory

(URL: )

Manabu KUROBOSHI, Associate Professor

Research Themes:

  • Electrosynthesis and Application of Organic Reductants
  • Synthesis of Phosphazene Derivatives by Electrooxidation
  • C-C Bond Formation by Using Transition Metal Catalyst/Viologen System
  • Electrooxidation/Reduction of Organophosphorus Compounds
  • Photoreduction of Viologen

Representative Publication :

  • Hiromu Kawakubo, Manabu Kuroboshi, Tomotake Yano, Kazuma Kobayashi, Syogo Kamenoue, Tomomi Akagi and Hideo Tanaka, “Electroreduction of Triphenylphosphine Oxide to Triphenylphosphine in the Presence of Chlorotrimethylsilane,” Synthesis 2011, 24, 4091-4098.

Industrial Catalysis Laboratory

(URL:http://www.cc.okayama-u.ac.jp/~oshiki/e/index.html)

Toshiyuki OSHIKI, Senior Assistant Professor

Research Themes:

  • New Tungsten Catalysts for the Ring Opening Metathesis Polymerization of Dicyclopentadiene
  • Hydration of Organonitriles by Ruthenium Complexes Using a Minimum Amount of Water

Representative Publication :

  • Makoto Muranaka, Isao Hyodo, Wataru Okumura and Toshiyuki Oshiki, “2-Diphenylphosphanyl-4-Pyridyl(dimethyl)Amine as an Effective Ligand for the Ruthenium(II) Complex Catalyzed Homogeneous Hydration of Nitriles Under Neutral Conditions,” Catalysis Today, Vol. 164, pp. 552-555, April 2011.

Bioprocess Engineering Laboratory

(URL: )

Koreyoshi IMAMURA, Professor

Naoyuki ISHIDA, Associate Professor

Hiroyuki IMANAKA, Assistant Professor

Research Themes:

  • Science and Engineering of Amorphous Sugar Matrix
  • Direct Measurement of Surface-Surface, Surface-Molecule, and Intermolecular Interactions in Liquid Phase
  • Applications of Controlled Protein Immobilization Methods to Biotechnology and Life Sciences
  • Functional Immobilization of Biomolecules on Solid Surfaces

Representative Publication :

  • Tomo Satoh, Fumihiro Hidaka, Kento Miyake, Natsumi Yoshiyama, Koji Takeda, Tsutashi Matsuura, Hiroyuki Imanaka, Naoyuki Ishida and Koreyoshi Imamura, “Surfactant-Free Solid Dispersion of Fat-Soluble Flavour in an Amorphous Sugar Matrix,” Food Chemistry,Vol. 197, pp. 1136-1142, April 2016.

Bioorganic Chemistry Laboratory

(URL:http://www.cc.okayama-u.ac.jp/~sakakura/)

Akira SAKAKURA, Professor

Ichiro HAYAKAWA, Associate Professor

Haruki MIZOGUCHI, Assistant Professor

Research Themes:

  • Total Synthesis of Bioactive Compounds
  • Design of Challenging Strategy for Organic Synthesis
  • Development of Highly Selective Carbon-Carbon Bond Formation Reactions
  • Rational Design of Chiral Acid-Base Cooperative Organocatalysts

Representative Publication :

  • Takayuki Kudoh, Yuya Araki, Natsumi Miyoshi, Mizuho Tanioka, Akira Sakakura, “Diastereodivergent Henry Reaction for the Stereoselective Construction of Nitrogen-Containing Tetrasubstituted Carbons: Application to Total Synthesis of Manzacidins A and C,” Asian Journal of Organic Chemistry, Vol. 6, No. 12, pp. 1760-1763, 2017.

Functional Molecular Engineering Laboratory

(URL:http://www.tt.vbl.okayama-u.ac.jp/)

Yuta NISHINA, Associate Professor

Research Themes:

  • Synthesis, Characterization and Application of Functional Nanocarbons
  • Application for Energy Devices: Li-ion Battery, Supercapacitor, Biofuel Cell, Fuel Cell
  • Application for Catalysts: Metal Nanoparticle Catalyst, Metal-free Catalyst
  • Application for Biology: Antibacterial Agent, Interaction with siRNA
  • Application for Environmental Industry: Water Purification, Biomass Transformation

Representative Publication :

  • Naoki Morimoto, Hideyuki Suzuki, Yasuo Takeuchi, Shogo Kawaguchi, Masahiro Kunisu, Christopher W. Bielawski, and Yuta Nishina, “Real-Time, in Situ Monitoring of the Oxidation of Graphite: Lessons Learned”, Chem. Mater. 2017, 29, 2150-2156.

Design of Biofunctional Molecules Laboratory

(URL:https://www.okayama-u.ac.jp/user/seralab/index.html)

Takashi SERA, Professor

Takamasa TOBIMATSU, Associate Professor

Koichi MORI, Assistant Professor

Kazuko KAWANAMI, Research Associate

Research Themes:

  • Design and Application of Artificial DNA/RNA-Binding Proteins
  • Regulation of Endogenous Gene Expression by Using Zinc-Finger-Based Artificial Transcription Factors
  • Development of Plants Resistant to Virus Infection and Antivirus Drugs
  • Development of Molecular Tools for Genome Engineering
  • Analysis of Enzyme Mechanisms and Molecular Engineering of Enzymes

Representative Publication :

  • Etsuko Yokota, Tomoki Yamatsuji, Munenori Takaoka, Minoru Haisa, Nagio Takigawa, Noriko Miyake, Tomoko Ikeda, Tomoaki Mori, Serika Ohno, Takashi Sera, Takuya Fukazawa, Yoshio Naomoto, “Targeted silencing of SOX2 by an artificial transcription factor showed antitumor effect in lung and esophageal squamous cell carcinoma,” Oncotarget, Volume 8, No.61, pp.103063-103076, October 2017.
  • Tomoaki Mori, Kento Nakamura, Keisuke Masaoka, Yusuke Fujita, Ryosuke Morisada, Koichi Mori, Takamasa Tobimatsu, and Takashi Sera, “Cleavage of influenza RNA by using a human PUF-based artificial RNA-binding protein–staphylococcal nuclease hybrid,” Biochemical and Biophysical Research Communications, Vol. 479, Issue 4, pp. 736-740, October 2016.
  • Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama and Takashi Sera, “Gene- and Protein-Delivered Zinc Finger-Staphylococcal Nuclease Hybrid for Inhibition of DNA Replication of Human Papillomavirus,” PLoS ONE, 8(2):e56633, February 2013.

Single Molecule Biology Laboratory

(URL: )

Toru IDE, Professor

Tohru HAYAKAWA, Assistant Professor

Research Themes:

  • Structure-Function Relationship of Ion-Channel Proteins
  • Development of High Throughput Screening Device for Ion-Channel Drugs
  • Development of Mosquito Control System Using Bacillus Thuringiensis Insecticidal Toxins
  • Development of Novel Protein Production System Using Polypeptides from Mosquitocidal Toxins

Representative Publication :

  • Mitsunori Kitta, Toru Ide, Minako Hirano, Hiroyuki Tanaka, Toshio Yanagida and Tomoji Kawai, “Direct Manipulation of a Single Potassium Channel Gate with an Atomic Force Microscope Probe,” Small, Vol. 7, No. 16, pp. 2379-2383, August 2011.

Applied Cell Biology Laboratory

(URL:http://www.okayama-u.ac.jp/user/saibou/)

Hiroshi TOKUMITSU, Professor

Naoki KANAYAMA, Associate Professor

Masaki MAGARI, Assistant Professor

Research Themes:

  • Molecular Mechanism of Intracellular Ca2+-Signal Transduction in Eukaryotic Cells
  • Structure and Function of Protein Kinases Including Development of Pharmacological Inhibitors
  • Cellular and Molecular Mechanisms of Immune Cell Functions Using Animal Cell Lines and Laboratory Animals Such as Mice

Representative Publication :

  • Akihiro Nakanishi, Noya Hatano, Yuya Fujiwara Y, Arian Sha’ri, Shota Takabatake, Hiroki Akano, Naoki Kanayama, Masaki Magari, Naohito Nozaki, and Hiroshi Tokumitsu, “AMP-activated protein kinase-mediated feedback phosphorylation controls the Ca2+/calmodulin (CaM) dependence of Ca2+/CaM-dependent protein kinase kinase β,” Journal of Biological Chemistry Vol. 292 No. 48, pp.19804-19813, December 2017
  • Yuya Fujiwara, Yoshinori Kawaguchi, Tomohito Fujimoto, Naoki Kanayama, Masaki Magari, and Hiroshi Tokumitsu, “Differential AMP-activated Protein Kinase (AMPK) Recognition Mechanism of Ca2+/Calmodulin-dependent Protein Kinase Kinase Isoforms,” Journal of Biological Chemistry Vol. 291 No. 26, pp.13802-13808, May 2016

Biomaterials Engineering Laboratory

(URL:http://apatite.biotech.okayama-u.ac.jp/en/index.html)

Satoshi HAYAKAWA, Professor

Tomohiko YOSHIOKA, Associate Professor

Toshiisa KONISHI, Assistant Professor

Research Themes:

  • Development of Bioactive Nanophase Ceramics for Biomedical Application
  • Structure and Physico-Chemical Properties of Calcium Phosphate-Based Ceramic Materials
  • Surface Modification of Metallic Implant Materials
  • Preparation of Novel Biomaterials by Electrochemical Techniques
  • Development of Calcium-Phosphate Bioceramics with Enhanced Biological Properties

Representative Publication :

  • Satoshi Hayakawa, Yuko Matsumoto, Keita Uetsuki, Yuki Shirosaki and Akiyoshi Osaka, “In Vitro Apatite Formation on Nano- crystalline Titania Layer Aligned Parallel to Ti6Al4V Alloy Substrates with Sub-Millimeter Gap,” Journal of Materials Science: Materials in Medicine, Vol. 26, Issue 6: 190, 8 Pages, June 2015.

Biomolecular Engineering Laboratory

(URL:http://www.okayama-u.ac.jp/user/ohtsuki/field8-e.html)

Takashi OHTSUKI, Professor

Kazunori WATANABE, Assistant Professor

Research Themes:

  • Photochemical and Sonochemical Methods for Spatiotemporal Control of Cellular Functions
  • RNA Drug Delivery
  • Expansion of Translation System
  • Stress Response of Mammalian Cells

Representative Publication :

  • Takashi Ohtsuki, Shigeto Kanzaki, Sae Nishimura, Yoshio Kunihiro, Y., Masahiko Sisido, Kazunori Watanabe, “Phototriggered protein syntheses by using (7-diethylaminocoumarin-4-yl)methoxycarbonyl-caged aminoacyl tRNAs.” Nature Communications, Vol.7, pp, 12501, August 2016.

Medical Protein Engineering Laboratory

(URL: )

Junichiro FUTAMI, Associate Professor

Research Themes:

  • Solubilization Techniques of Denatured Protein
  • Development of Companion Diagnostics for Cancer Immunotherapy
  • Intracellular Delivery of Protein and in Cell Protein Folding

Representative Publication :

  • Junichiro Futami, Hidenori Nonomura, Momoko Kido, Naomi Niidoi, Nao Fujieda, Akihiro Hosoi, Kana Fujita, Komako Mandai, Yuki Atago, Rie Kinoshita, Tomoko Honjo, Hirokazu Matsushita, Akiko Uenaka, Eiichi Nakayama and Kazuhiro Kakimi, “Sensitive Multiplexed Quantitative Analysis of Autoantibodies to Cancer Antigens with Chemically S-Cationized Full-Length and Water-Soluble Denatured Proteins,” Bioconjugate Chemistry, Vol. 26, No. 10, pp. 2076-2084, October 2015.

Nano-Biotechnology Laboratory

(URL:http://www.cyber.biotech.okayama-u.ac.jp/senolab/)

Masaharu SENO, Professor

Hiroshi MURAKAMI, Associate Professor

Junko MASUDA, Assistant Professor

Research Themes:

  • Development of Cancer Stem Cells from Pluripotent Stem Cells
  • Tumor Microenvironment
  • Drug Delivery System Targeting Cancer Cells and Cancer Stem Cells
  • Analyses and Application of Factors that Control Cellular Growth and Differentiation

Representative Publication :

  • Nair N, Calle AS, Zahra MH, Prieto-Vila M, Oo AKK, Hurley L, Vaidyanath A, Seno A, Masuda J, Iwasaki Y, Tanaka H, Kasai T, Seno M.
    A cancer stem cell model as the point of origin of cancer-associated fibroblasts in tumor microenvironment. Sci Rep. 2017 Jul 28;7(1):6838. doi: 10.1038/s41598-017-07144-5. PubMed PMID: 28754894.

Organelle System Biotechnology Laboratory

(URL: )

Ayano SATOH, Associate Professor

Research Themes:

  • Membrane Trafficking
  • Organelle Biogenesis
  • Cell Biology and Diseases
  • Post-Translational Modifications

Representative Publication :

  • COPI-TRAPPII activates Rab18 and regulates its lipid droplet association, Li C, Luo X, Zhao S, Siu GK, Liang Y, Chan HC, Satoh A, Yu SS, EMBO J. 2017 Feb 15;36(4):441-457